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Norfloxacin
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Norfloxacin
Systematic (IUPAC) name
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-
3-carboxylic acid
Identifiers
CAS number 70458-96-7
ATC code J01MA06 S01AX12
PubChem 4539
DrugBank APRD00469
Chemical data
Formula C16H18FN3O3
Mol. mass 319.331 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life 3 to 4 hours
Excretion ?
Therapeutic considerations
Pregnancy cat.
?
Legal status
Routes ?
Norfloxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections.
[edit] Mechanism of action
The mechanism of action of norfloxacin involves inhibition of the A subunit of bacterial DNA gyrase, an enzyme which is essential for DNA replication.[1]
[edit] References
1. ^ Goldstein E (1987). "Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity". Am J Med 82 (6B): 3–17. PMID 3111257.
[hide]
v • d • e
Antibacterials for systemic use: quinolones (J01M)
Fluoroquinolones Ciprofloxacin • Enoxacin • Fleroxacin • Gatifloxacin • Gemifloxacin • Grepafloxacin • Levofloxacin • Lomefloxacin • Moxifloxacin • Norfloxacin • Ofloxacin • Pefloxacin • Prulifloxacin • Rufloxacin • Sparfloxacin • Temafloxacin • Trovafloxacin • Sitafloxacin
Other quinolones Cinoxacin • Flumequine • Nalidixic acid • Oxolinic acid • Pipemidic acid • Piromidic acid • Rosoxacin
Pills This antibiotic-related article is a stub. You can help Wikipedia by expanding it.
Retrieved from "http://en.wikipedia.org/wiki/Norfloxacin"
Categories: Antibiotic stubs | Fluoroquinolone antibiotics
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